SCHEMBL4338669

SCHEMBL4338669

O=C(c1ccc(Oc2ccccc2)cc1)c1ccc(Cl)cc1Cl

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.68
RAB9A P51151 1/20 0.68
SRD5A2 P31213 4/20 0.65
SERPINE1 P05121 1/20 0.54
POLB P06746 2/20 0.54
KMT2A Q03164 3/20 0.53
MEN1 O00255 2/20 0.53
GAA P10253 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
TSHR P16473 1/20 0.50
CASP1 P29466 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
BCL2 P10415 2/20 0.49
MCL1 Q07820 2/20 0.49
NR4A1 P22736 1/20 0.49
TP53 P04637 1/20 0.48
STK39 Q9UEW8 1/20 0.48
CYP2C9 P11712 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL596448 0.88 SERPINE1 (0.58) MAPTRAB9ASRD5A2SERPINE1POLB
SCHEMBL197240 0.88 SERPINE1 (0.58) MAPTRAB9ASRD5A2SERPINE1POLB
SCHEMBL27874063 0.88 POLB (0.60) MAPTRAB9ASRD5A2POLBKMT2A
SCHEMBL13371482 0.87 SRD5A2 (0.57) MAPTRAB9ASRD5A2SERPINE1POLB
SCHEMBL3675416 0.87 SRD5A2 (0.57) MAPTRAB9ASRD5A2SERPINE1POLB
SCHEMBL522683 0.85 SRD5A2 (0.74) MAPTRAB9ASRD5A2POLBKMT2A
SCHEMBL29350361 0.85 SRD5A2 (0.74) MAPTRAB9ASRD5A2POLBKMT2A
SCHEMBL28033215 0.84 KMT2A (0.71) SRD5A2POLBKMT2ATDP1BCL2
SCHEMBL12360590 0.84 POLB (0.56) MAPTRAB9ASRD5A2SERPINE1POLB
SCHEMBL9777076 0.83 KMT2A (0.69) MAPTRAB9ASRD5A2POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2112133-B1 Halogenated aromatic compound, polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2012-07-04 EP disclosed
EP-2112133-A1 Halogenated aromatic compound, polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2009-10-28 EP disclosed
EP-1245555-B1 Halogenated aromatic compound, polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2009-08-19 EP disclosed
EP-1138712-B1 Polyarylene copolymers and proton-conductive membrane JSR CORP (JP) 2006-01-18 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
EP-1245554-B1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORP (JP) 2005-01-26 EP disclosed
US-6825310-B2 POLYETHER KETONE POLYMERS PROVIDE STABLE MECHANICAL AND THERMAL PROPERTIES (DURABILITY) WHEN SULFONATED; FOR USE IN BATTERIES/FUEL CELLS JSR CORPORATION (JP) 2004-11-30 US disclosed
US-6812290-B2 FOR USE AS ELECTROLYTES JSR CORPORATION (JP) 2004-11-02 US disclosed
US-6794480-B2 POLYARYLENE-BASED COPOLYMER USEFUL AS PROTON-CONDUCTIVE MEMBRANE WHICH CAN BE USED AS ELECTRON FOR PRIMARY BATTERY, ELECTROLYTE FOR SECONDARY BATTERY, HIGH MOLECULAR SOLID ELECTROLYTE FOR FUEL CELL JSR CORPORATION (JP) 2004-09-21 US disclosed
US-20030195301-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2003-10-16 US disclosed
US-6555626-B2 Controlled amount of sulfonic acid groups; copolymer of an aromatic compound having a main chain containing electron withdrawing groups and aromatic compounds with no electron withdrawing groups; durability, strength, conductivity JSR CORPORATION (JP) 2003-04-29 US disclosed
US-20020188097-A1 Polyether ketone polymers provide stable mechanical and thermal properties (durability) when sulfonated; for use in batteries/fuel cells JSR CORPORATION (JP) 2002-12-12 US disclosed
US-20020177656-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORPORATION (JP) 2002-11-28 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
EP-1245555-A1 Halogenated aromatic compound, polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed
EP-1245554-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed
US-20010037000-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2001-11-01 US disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed