Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.39 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.39 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoquinoline SCHEMBL4339108 | 1.00 | IMPDH2 (0.46) | IMPDH2L3MBTL1CYP3A4SLC22A12UBE2N | |
| Isoquinoline SCHEMBL27990251 | 1.00 | IMPDH2 (0.46) | IMPDH2L3MBTL1CYP3A4SLC22A12UBE2N | |
| Isoquinoline SCHEMBL5527333 | 0.95 | IMPDH2 (0.43) | IMPDH2L3MBTL1CYP3A4SLC22A12UBE2N | |
| Isoquinoline SCHEMBL8545526 | 0.95 | IMPDH2 (0.43) | IMPDH2L3MBTL1CYP3A4SLC22A12UBE2N | |
| Isoquinoline SCHEMBL8545344 | 0.91 | CCNC (0.42) | IMPDH2L3MBTL1CYP3A4SLC22A12UBE2N | |
| Trifluoroacetic Acid SCHEMBL30343227 | 0.90 | L3MBTL1 (0.42) | IMPDH2L3MBTL1CYP3A4SLC22A12UBE2N | |
| Isoquinoline SCHEMBL11346369 | 0.86 | IMPDH2 (0.53) | IMPDH2CYP3A4CCNCCDK8ROCK2 | |
| Isoquinoline SCHEMBL4353462 | 0.84 | IMPDH2 (0.51) | IMPDH2CYP3A4CCNCCDK8ROCK2 | |
| Isoquinoline SCHEMBL523706 | 0.82 | IMPDH2 (0.50) | IMPDH2CYP3A4SLC22A12CCNCCDK8 | |
| Isoquinoline SCHEMBL2230386 | 0.82 | IMPDH2 (0.50) | IMPDH2L3MBTL1CYP3A4CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120938-A1 | IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085302-A1 | IMIDAZOPYRIDINE ANALOGS AS CB2 RECEPTOR MODULATORS, USEFUL IN THE TREATMENT OF PAIN, RESPIRATORY AND NON-RESPIRATORY DISEASES | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |