Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30340510 | 0.79 | GLO1 (0.57) | ALDH1A1 | |
| SCHEMBL31632888 | 0.78 | KDM4C (0.47) | ALDH1A1KDM4E | |
| SCHEMBL4789449 | 0.75 | PDE1B (0.46) | LMNAALDH1A1MAPTKDM4E | |
| SCHEMBL29730634 | 0.74 | ALDH1A1 (0.48) | LMNARECQLALDH1A1MAPT | |
| SCHEMBL17193676 | 0.74 | ALDH1A1 (0.48) | LMNARECQLALDH1A1MAPT | |
| SCHEMBL23035775 | 0.74 | — | — | |
| SCHEMBL29685884 | 0.73 | RECQL (0.43) | LMNARECQLALDH1A1KDM4EPTGS1 | |
| SCHEMBL14000509 | 0.71 | RECQL (0.65) | RECQLALDH1A1TSHRNAMPT | |
| SCHEMBL25412409 | 0.71 | RECQL (0.60) | RECQLALDH1A1KDM4EPTGS1 | |
| SCHEMBL30614221 | 0.71 | RECQL (0.60) | RECQLALDH1A1KDM4EPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539753-B1 | PYRAZOLO(3,4-B)PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2009-09-09 | — | — | EP | disclosed |