Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CFTR | P13569 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180693 | 0.83 | MAPT (0.60) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL27769454 | 0.82 | MEN1 (0.67) | MAPTNPSR1MAPK1ALOX5POLB | |
| SCHEMBL12298071 | 0.81 | VCP (0.80) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL7263150 | 0.81 | VCP (0.80) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL7267313 | 0.81 | VCP (0.80) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL917730 | 0.80 | CFTR (0.63) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL23553570 | 0.80 | VCP (1.00) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL7262430 | 0.80 | VCP (0.78) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL1887941 | 0.80 | VCP (0.78) | VCPMAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL4335531 | 0.79 | MEN1 (0.54) | VCPMAPTNPSR1ALOX5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | claimed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | claimed |
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |