Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.43 |
| ▸ | CCR4 | P51679 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27769670 | 0.84 | RAB9A (0.46) | MEN1KMT2AMAPTNPSR1ALOX5 | |
| SCHEMBL4939307 | 0.83 | DGAT1 (0.50) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL14127473 | 0.81 | NPY5R (0.63) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL4340445 | 0.79 | VCP (0.67) | MEN1KMT2AMAPTNPSR1ALOX5 | |
| SCHEMBL1883090 | 0.79 | MAPT (0.63) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL14127231 | 0.77 | MEN1 (0.64) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL23539804 | 0.72 | MEN1 (0.60) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL30042551 | 0.72 | MEN1 (0.60) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL14127267 | 0.72 | MEN1 (0.61) | MEN1KMT2AGAAMAPTNPSR1 | |
| SCHEMBL16137404 | 0.71 | NPY5R (0.65) | MEN1KMT2AGAAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | claimed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | claimed |
| EP-2117526-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008067257-A2 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-06-05 | — | — | WO | disclosed |