Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3049283 | 0.92 | POLB (0.65) | POLBSIGMAR1RAB9AMEN1KMT2A | |
| SCHEMBL3038901 | 0.86 | RAB9A (0.60) | POLBRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL3050521 | 0.83 | POLB (0.71) | POLBSIGMAR1RAB9AMEN1KMT2A | |
| SCHEMBL3051897 | 0.80 | POLB (0.73) | POLBMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4340481 | 0.79 | HTT (0.42) | POLBSIGMAR1RAB9AHTR2AALDH1A1 | |
| SCHEMBL3047425 | 0.79 | MAPT (0.62) | POLBRAB9AKMT2ASMN1; SMN2HTR2A | |
| SCHEMBL3055296 | 0.76 | POLB (0.67) | POLBSIGMAR1RAB9AMEN1KMT2A | |
| SCHEMBL3047069 | 0.75 | POLB (0.57) | POLBSIGMAR1RAB9AMEN1KMT2A | |
| SCHEMBL3042587 | 0.75 | POLB (0.69) | POLBMEN1KMT2AHTR2ANPSR1 | |
| SCHEMBL3045219 | 0.73 | HTR2A (0.56) | POLBRAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434765-B1 | SUBSTITUTED PIPERIDINES WITH SELECTIVE BINDING TO HISTAMINE H3-RECEPTOR | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-12-02 | — | — | EP | claimed |