Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4340461 | 0.79 | POLB (0.57) | HTR2AALDH1A1GAAHTR2CL3MBTL1 | |
| SCHEMBL3049283 | 0.73 | POLB (0.65) | ALDH1A1GAAL3MBTL1GHSRCCR5 | |
| SCHEMBL12004767 | 0.69 | GHSR (0.46) | HTR2AGHSRCCR5 | |
| SCHEMBL15088420 | 0.69 | MCHR1 (0.67) | HTR2AALDH1A1GAAHTR2CL3MBTL1 | |
| SCHEMBL3038901 | 0.67 | RAB9A (0.60) | HTTHTR2AALDH1A1GAAHTR2C | |
| SCHEMBL3050521 | 0.66 | POLB (0.71) | ALDH1A1GAACCR5POLBSIGMAR1 | |
| SCHEMBL19309199 | 0.66 | GHSR (0.70) | HTTGHSR | |
| SCHEMBL12005988 | 0.66 | GHSR (0.70) | HTTGHSR | |
| SCHEMBL12004450 | 0.66 | GHSR (0.55) | HTTHTR2AHTR2CGHSRCCR5 | |
| SCHEMBL30804735 | 0.66 | MCHR1 (0.53) | ALDH1A1GAAL3MBTL1POLBMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434765-B1 | SUBSTITUTED PIPERIDINES WITH SELECTIVE BINDING TO HISTAMINE H3-RECEPTOR | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-12-02 | — | — | EP | claimed |