Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.40 |
| ▸ | IAPP | P10997 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | BCL9 | O00512 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434794 | 0.88 | TSHR (0.38) | TSHRAKR1B1IAPPALDH1A1HPGD | |
| SCHEMBL28305789 | 0.82 | TSHR (0.55) | TSHRAKR1B1ALDH1A1HPGDNLRP3 | |
| SCHEMBL27459370 | 0.78 | SMN1; SMN2 (0.49) | AKR1B1IAPPALDH1A1HPGDBCL9 | |
| SCHEMBL27548181 | 0.77 | TSHR (0.50) | TSHRAKR1B1ALDH1A1NLRP3LDHA | |
| SCHEMBL11048420 | 0.77 | ALDH1A1 (0.37) | TSHRIAPPALDH1A1HPGDNAMPT | |
| SCHEMBL28338340 | 0.77 | ALDH1A1 (0.52) | TSHRALDH1A1HPGDNLRP3GAA | |
| SCHEMBL28973299 | 0.77 | IAPP (0.43) | TSHRIAPPALDH1A1BCL9CTNNB1 | |
| SCHEMBL28305792 | 0.76 | TSHR (0.49) | TSHRAKR1B1ALDH1A1HPGDLDHA | |
| SCHEMBL19335394 | 0.76 | NAMPT (0.41) | AKR1B1ALDH1A1NAMPTELANECA12 | |
| SCHEMBL8487851 | 0.76 | KDM4E (0.50) | IAPPALDH1A1HPGDBCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595952-B1 | AGONISTS OF GPR40 | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2020-11-18 | — | — | EP | disclosed |
| EP-2595952-A1 | AGONISTS OF GPR40 | Connexios Life Sciences Pvt. Ltd. (IN) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012011125-A1 | AGONISTS OF GPR40 | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |