Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 6/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.53 |
| ▸ | AXL | P30530 | 6/20 | 0.53 |
| ▸ | FLT4 | P35916 | 6/20 | 0.53 |
| ▸ | FLT3 | P36888 | 6/20 | 0.53 |
| ▸ | CLK2 | P49760 | 6/20 | 0.53 |
| ▸ | CAMK2B | Q13554 | 6/20 | 0.53 |
| ▸ | CAMK2G | Q13555 | 6/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 6/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 6/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 6/20 | 0.53 |
| ▸ | SLK | Q9H2G2 | 6/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.53 |
| ▸ | SGK2 | Q9HBY8 | 6/20 | 0.53 |
| ▸ | EGFR | P00533 | 6/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.53 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.53 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343461 | 1.00 | PRKD3 (0.53) | PRKD3NTRK1AXLFLT4FLT3 | |
| SCHEMBL4349084 | 0.89 | CLK1 (0.53) | AXLDYRK1AROCK1ROCK2STK3 | |
| SCHEMBL4349076 | 0.89 | CLK1 (0.53) | AXLDYRK1AROCK1ROCK2STK3 | |
| SCHEMBL4348302 | 0.89 | PRKD3 (0.56) | PRKD3NTRK1AXLFLT4FLT3 | |
| SCHEMBL4348312 | 0.89 | PRKD3 (0.56) | PRKD3NTRK1AXLFLT4FLT3 | |
| SCHEMBL4351217 | 0.85 | MAP3K7 (0.47) | PRKD3NTRK1AXLFLT4FLT3 | |
| SCHEMBL4351213 | 0.85 | MAP3K7 (0.47) | PRKD3NTRK1AXLFLT4FLT3 | |
| SCHEMBL4346709 | 0.84 | MAP3K7 (0.48) | NTRK1ROCK1ROCK2BTKMAP3K7 | |
| SCHEMBL4346713 | 0.84 | MAP3K7 (0.48) | NTRK1ROCK1ROCK2BTKMAP3K7 | |
| SCHEMBL5261041 | 0.83 | PRKD3 (0.53) | PRKD3NTRK1AXLFLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |