Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | STK3 | Q13188 | 1/20 | 0.46 |
| ▸ | STK11 | Q15831 | 1/20 | 0.46 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349076 | 1.00 | CLK1 (0.53) | CLK1DYRK1AAAK1RAB9ASMN1; SMN2 | |
| SCHEMBL4343461 | 0.89 | PRKD3 (0.53) | CLK1DYRK1AAAK1PIM1PIM3 | |
| SCHEMBL4343457 | 0.89 | PRKD3 (0.53) | CLK1DYRK1AAAK1PIM1PIM3 | |
| SCHEMBL4348312 | 0.82 | PRKD3 (0.56) | DYRK1ARAB9ASMN1; SMN2NPC1PIM1 | |
| SCHEMBL4348302 | 0.82 | PRKD3 (0.56) | DYRK1ARAB9ASMN1; SMN2NPC1PIM1 | |
| SCHEMBL16932946 | 0.80 | DYRK1A (0.53) | DYRK1AAAK1PIM1PIM3AXL | |
| SCHEMBL16932944 | 0.80 | DYRK1A (0.53) | DYRK1AAAK1PIM1PIM3AXL | |
| SCHEMBL13821456 | 0.80 | BMX (0.55) | RAB9ASMN1; SMN2NPC1LMNATDP1 | |
| SCHEMBL4346952 | 0.79 | MAP3K7 (0.43) | CLK1DYRK1APIM1AXLSTK3 | |
| SCHEMBL4346955 | 0.79 | MAP3K7 (0.43) | CLK1DYRK1APIM1AXLSTK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |