Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAP2 | P11137 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197511 | 0.83 | BRD4 (0.46) | BRD4CCNT1CDK9CDC7 | |
| SCHEMBL4344585 | 0.81 | BRD4 (0.45) | BRD4CCNT1CDK9JAK2MEN1 | |
| SCHEMBL4344042 | 0.81 | BRD4 (0.38) | BRD4CCNT1CDK9MEN1KMT2A | |
| SCHEMBL2196441 | 0.81 | BRD4 (0.44) | BRD4CCNT1CDK9MEN1KMT2A | |
| SCHEMBL2202784 | 0.80 | BRD4 (0.41) | BRD4CCNT1CDK9IKBKBKMT2A | |
| SCHEMBL4339928 | 0.79 | CCNT1 (0.37) | BRD4CCNT1CDK9ABL1 | |
| SCHEMBL2198985 | 0.79 | MAPT (0.47) | BRD4CCNT1CDK9JAK2MEN1 | |
| SCHEMBL2197617 | 0.78 | BRD4 (0.41) | BRD4CCNT1CDK9JAK2MEN1 | |
| SCHEMBL2198205 | 0.77 | BRD4 (0.40) | BRD4CCNT1CDK9JAK2MEN1 | |
| SCHEMBL2195955 | 0.77 | CDK9 (0.42) | BRD4CCNT1CDK9CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116530-B1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-14 | — | — | EP | disclosed |
| EP-2116530-A1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-11 | — | — | EP | disclosed |