Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL4344174 | 0.78 | FBP1 (0.69) | FBP1 | |
| SCHEMBL958688 | 0.78 | FBP1 (0.71) | FBP1 | |
| SCHEMBL4344180 | 0.77 | FBP1 (0.46) | FBP1FFAR2CCNE1CDK2CDK5 | |
| Methane SCHEMBL4344184 | 0.77 | FBP1 (0.70) | FBP1 | |
| SCHEMBL4757984 | 0.62 | CCNE1 (0.65) | FFAR2CCNE1CDK2CDK5LMNA | |
| SCHEMBL956186 | 0.61 | FBP1 (1.00) | FBP1 | |
| SCHEMBL703141 | 0.61 | MEN1 (0.52) | CCNE1CDK2CDK5NPC1RAB9A | |
| SCHEMBL4756445 | 0.59 | STAT3 (0.60) | FFAR2CCNE1CDK2CDK5LMNA | |
| SCHEMBL16918830 | 0.59 | CCNE1 (0.57) | CCNE1CDK2CDK5LMNAMAPT | |
| SCHEMBL14274086 | 0.59 | HDAC3 (0.48) | FBP1LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032548-A1 | THIAZOLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007137962-A1 | THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-06 | — | — | WO | disclosed |