Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 13/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.48 |
| ▸ | FLT4 | P35916 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.48 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.48 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.48 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.48 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344188 | 1.00 | HDAC1 (0.52) | HDAC1GSK3BNAMPTPRKD3MAP4K4 | |
| SCHEMBL4343841 | 0.88 | GSK3B (0.51) | HDAC1GSK3BNAMPTPLAUMMP1 | |
| SCHEMBL4343847 | 0.88 | GSK3B (0.51) | HDAC1GSK3BNAMPTPLAUMMP1 | |
| SCHEMBL4346687 | 0.87 | GSK3B (0.49) | HDAC1GSK3BPLAUMMP1MMP2 | |
| SCHEMBL4346683 | 0.87 | GSK3B (0.49) | HDAC1GSK3BPLAUMMP1MMP2 | |
| SCHEMBL4343457 | 0.83 | PRKD3 (0.53) | GSK3BPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL4343461 | 0.83 | PRKD3 (0.53) | GSK3BPRKD3MAP4K4NTRK1AXL | |
| SCHEMBL13821714 | 0.83 | GSK3B (0.51) | HDAC1GSK3BPRKD3MAP4K4NTRK1 | |
| SCHEMBL24758015 | 0.83 | PLAU (0.60) | HDAC1GSK3BPLAUMMP1MMP2 | |
| SCHEMBL31107440 | 0.83 | PLAU (0.60) | HDAC1GSK3BPLAUMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |