Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346683 | 1.00 | GSK3B (0.49) | GSK3BPLAUBTKHDAC1MMP1 | |
| SCHEMBL4343841 | 0.87 | GSK3B (0.51) | GSK3BPLAUHDAC1MMP1MMP2 | |
| SCHEMBL4343847 | 0.87 | GSK3B (0.51) | GSK3BPLAUHDAC1MMP1MMP2 | |
| SCHEMBL4344181 | 0.87 | HDAC1 (0.52) | GSK3BPLAUHDAC1MMP1MMP2 | |
| SCHEMBL4344188 | 0.87 | HDAC1 (0.52) | GSK3BPLAUHDAC1MMP1MMP2 | |
| SCHEMBL24758015 | 0.81 | PLAU (0.60) | GSK3BPLAUHDAC1MMP1MMP2 | |
| SCHEMBL31107440 | 0.81 | PLAU (0.60) | GSK3BPLAUHDAC1MMP1MMP2 | |
| SCHEMBL4350420 | 0.80 | MAP3K7 (0.46) | BTK | |
| SCHEMBL4350414 | 0.80 | MAP3K7 (0.46) | BTK | |
| SCHEMBL4346212 | 0.77 | GSK3B (0.58) | GSK3BHDAC1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |