Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 1.00 |
| ▸ | MAPT | P10636 | 11/20 | 0.79 |
| ▸ | ALOX12 | P18054 | 6/20 | 0.79 |
| ▸ | GAA | P10253 | 3/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.77 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | MYC | P01106 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344714 | 1.00 | ALDH1A1 (1.00) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4334387 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4334391 | 0.87 | ALDH1A1 (1.00) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4322235 | 0.84 | ALDH1A1 (0.72) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4322231 | 0.84 | ALDH1A1 (0.72) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4334914 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4334911 | 0.82 | ALDH1A1 (1.00) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4329376 | 0.80 | MAPT (0.81) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4329373 | 0.80 | MAPT (0.81) | ALDH1A1MAPTALOX12GAASMN1; SMN2 | |
| SCHEMBL4339996 | 0.78 | ALDH1A1 (0.78) | ALDH1A1MAPTALOX12GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090285849-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2009-11-19 | — | — | US | disclosed |
| US-7521062-B2 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES & DIAGNOSTICS, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-20050069555-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090285849-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | MAVS, IRF3, HAVCR2 | ALDH1A1 1459/4885MAPT 3619/4885ALOX12 1149/4885 |
| US-20050069555-A1 | Thiosemicarbazones as anti-virals and immunopotentiators | MAVS, IRF3, HAVCR2 | ALDH1A1 1173/4885MAPT 3876/4885ALOX12 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.