Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 9/20 | 0.39 |
| ▸ | RCOR1 | Q9UKL0 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14401494 | 1.00 | KDM4E (0.41) | KDM4EKDM1ARCOR1MAOAMAOB | |
| SCHEMBL13914853 | 1.00 | KDM4E (0.41) | KDM4EKDM1ARCOR1MAOAMAOB | |
| SCHEMBL10750172 | 0.71 | KDM1A (0.46) | KDM1ARCOR1MAOB | |
| SCHEMBL28559261 | 0.70 | KDM1A (0.46) | KDM4EKDM1ARCOR1MAOAMAOB | |
| SCHEMBL31083268 | 0.70 | KDM1A (0.46) | KDM4EKDM1ARCOR1MAOAMAOB | |
| SCHEMBL14401495 | 0.68 | ADAM17 (0.50) | HTR2C | |
| SCHEMBL4338557 | 0.68 | ADAM17 (0.50) | HTR2C | |
| SCHEMBL13914852 | 0.68 | ADAM17 (0.50) | HTR2C | |
| SCHEMBL4338559 | 0.68 | ADAM17 (0.50) | HTR2C | |
| SCHEMBL13045928 | 0.68 | KCNH2 (0.39) | MAOAMAOBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501453-B2 | Cyclopropanes with central nervous system activity | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070244201-A1 | Cyclopropanes with central nervous system activity | NIH-DEITR | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244201-A1 | Cyclopropanes with central nervous system activity | PMP22, CNR1, CNR2 | KDM4E 4301/4885KDM1A 4710/4885RCOR1 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.