Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.34 |
| ▸ | STAT6 | P42226 | 2/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | PYGM | P11217 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.32 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.32 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856901 | 0.87 | STAT6 (0.38) | SMYD3CYP51A1STAT6PYGLPYGM | |
| SCHEMBL19856903 | 0.87 | STAT6 (0.38) | SMYD3CYP51A1STAT6PYGLPYGM | |
| SCHEMBL4343724 | 0.86 | CYP51A1 (0.36) | SMYD3CYP51A1STAT6PYGLPYGM | |
| SCHEMBL19856965 | 0.85 | TDP1 (0.36) | SMYD3CYP51A1STAT6PYGLKDM4E | |
| SCHEMBL4335350 | 0.85 | TDP1 (0.36) | SMYD3CYP51A1STAT6PYGLKDM4E | |
| SCHEMBL19856915 | 0.85 | TDP1 (0.36) | SMYD3CYP51A1STAT6PYGLKDM4E | |
| SCHEMBL4343721 | 0.85 | TDP1 (0.36) | SMYD3CYP51A1STAT6PYGLKDM4E | |
| SCHEMBL19857011 | 0.84 | SMYD3 (0.37) | SMYD3HCRTR1HCRTR2CYP51A1STAT6 | |
| SCHEMBL4350449 | 0.81 | HTRA1 (0.36) | SMYD3CYP51A1STAT6PYGLKDM4E | |
| SCHEMBL4341332 | 0.81 | HTRA1 (0.36) | SMYD3CYP51A1STAT6PYGLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | claimed |
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |