Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29227142 | 0.88 | NPC1 (0.79) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL29227127 | 0.88 | MAPT (0.79) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10902286 | 0.88 | NPC1 (0.79) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL30679624 | 0.88 | MAPT (0.79) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL29227155 | 0.88 | MAPT (0.79) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5662106 | 0.85 | NPC1 (0.73) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL31573995 | 0.85 | MAPT (0.73) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL31573986 | 0.85 | RAB9A (0.73) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL31573994 | 0.85 | RAB9A (0.73) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5663499 | 0.85 | NPC1 (0.73) | NPC1MAPTRAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117946031-A | Substituted aromatic phenol derivatives of KNa1.1 channel inhibitors | 北京大学 | 2024-04-30 | — | — | CN | disclosed |
| WO-2024010732-A1 | SMALL MOLECULE INHIBITORS OF GLUTAMINE TRANSPORTER ASCT2 AND METHODS OF USE THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-01-11 | — | — | WO | disclosed |
| EP-2872490-B1 | ANTIPROLIFERATIVE BENZO[B]AZEPIN-2-ONES | HOFFMANN LA ROCHE (CH) | 2018-02-07 | — | — | EP | disclosed |
| US-9809672-B2 | Aromatic resins for underlayers | ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) | 2017-11-07 | — | — | US | disclosed |
| US-9765016-B2 | S1P modulating agents | BIOGEN MA INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765016-B2 | S1P modulating agents | BIOGEN MA INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765016-B2 | S1P modulating agents | BIOGEN MA INC. (US) | 2017-09-19 | — | — | US | disclosed |
| CN-105026360-B | S1P conditioning agents | 比奥根MA公司 | 2017-08-25 | — | — | CN | disclosed |
| CN-104507913-B | The antiproliferative ketone of benzo [b] azepine * 2 | 霍夫曼-拉罗奇有限公司 | 2017-07-28 | — | — | CN | disclosed |
| US-9611224-B2 | Antiproliferative benzo [B] azepin-2-ones | HOFFMANN-LA ROCHE INC. (US) | 2017-04-04 | — | — | US | disclosed |
| EP-0948495-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | Amgen Inc., (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5840739-A | Thiazoline acid derivatives | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| WO-1998022457-A9 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | — | 1998-08-20 | — | — | WO | disclosed |
| WO-1998022457-A1 | ARYL AND HETEROARYL SUBSTITUTED FUSED PYRROLE ANTIINFLAMMATORY AGENTS | AMGEN INC. (US) | 1998-05-28 | — | — | WO | disclosed |
| US-4656126-A | HIGH SIGNAL-TO-NOISE RATIOS AND HIGH IMAGE DENSITY | FUJI PHOTO FILM CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |
| US-4111962-A | Certain substituted 2-phenylnaphtho[1,2-b]furane and -[2,1-b]furane | STERLING DRUG INC. (US) | 1978-09-05 | — | — | US | disclosed |