Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.71 |
| ▸ | PPARD | Q03181 | 5/20 | 0.71 |
| ▸ | PPARA | Q07869 | 5/20 | 0.71 |
| ▸ | TERT | O14746 | 3/20 | 0.71 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | BLM | P54132 | 3/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.71 |
| ▸ | FABP4 | P15090 | 3/20 | 0.71 |
| ▸ | TOP1 | P11387 | 3/20 | 0.71 |
| ▸ | USP2 | O75604 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.71 |
| ▸ | RECQL | P46063 | 2/20 | 0.71 |
| ▸ | F7 | P08709 | 2/20 | 0.71 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.71 |
| ▸ | F3 | P13726 | 2/20 | 0.71 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.71 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL3941976 | 0.97 | TERT (0.75) | PPARGPPARDPPARATERTPTPN1 | |
| Bicarbonate SCHEMBL6246658 | 0.97 | TERT (0.75) | PPARGPPARDPPARATERTPTPN1 | |
| Bicarbonate SCHEMBL9812228 | 0.97 | TERT (0.75) | PPARGPPARDPPARATERTPTPN1 | |
| Bicarbonate SCHEMBL10592426 | 0.97 | TERT (0.75) | PPARGPPARDPPARATERTPTPN1 | |
| Bicarbonate SCHEMBL3789802 | 0.97 | TERT (0.75) | PPARGPPARDPPARATERTPTPN1 | |
| Bicarbonate SCHEMBL8442057 | 0.93 | PPARG (0.77) | PPARGPPARDPPARAMAPTBLM | |
| Acetic Acid SCHEMBL29431318 | 0.90 | TERT (0.72) | PPARGPPARDPPARATERTPTPN1 | |
| Acetic Acid SCHEMBL28365304 | 0.90 | TERT (0.72) | PPARGPPARDPPARATERTPTPN1 | |
| Acetic Acid SCHEMBL4487303 | 0.90 | TERT (0.72) | PPARGPPARDPPARATERTPTPN1 | |
| Acetic Acid SCHEMBL29159701 | 0.90 | TERT (0.72) | PPARGPPARDPPARATERTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253044-A1 | Nonaqueous Electrolyte and Lithium ion Secondary Battery Using Same | MITSUI CHEMICALS, INC. (JP) | 2009-10-08 | — | — | US | disclosed |