Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | GLA | P06280 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4347045 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL4346169 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL1368954 | 0.92 | MAOB (0.60) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL1365963 | 0.92 | HDAC1 (0.54) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL4356841 | 0.92 | MAOB (0.60) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL1365965 | 0.92 | HDAC1 (0.54) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL1368950 | 0.92 | MAOB (0.60) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL1369087 | 0.92 | HDAC1 (0.54) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL4339721 | 0.85 | MAOA (0.60) | ALDH1A1KDM4EHPGDGAAMAOB | |
| SCHEMBL1368410 | 0.85 | KMT2A (0.61) | ALDH1A1KDM4EHPGDGAAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-05 | — | — | US | claimed |
| WO-2006132947-A2 | 3-ACYL COUMARINS, THIOCHROMONES AND QUINOLONES AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-12-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275650-A1 | 3-Acyl coumarins, thiochromones and quinolones and therapeutic uses thereof | NQO2, NQO1, HCCS | ALDH1A1 617/4885KDM4E 2293/4885HPGD 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.