Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27777776 | 0.92 | POLB (0.53) | POLBHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL2542606 | 0.85 | POLB (0.49) | POLBHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL27710802 | 0.85 | POLB (0.52) | POLBHDAC3HDAC4HDAC7HDAC8 | |
| Benzylhydrazine SCHEMBL21925559 | 0.84 | IDO1 (0.46) | POLBSLC6A4SLC6A3ALDH1A1MAPT | |
| SCHEMBL28058220 | 0.84 | CYP3A4 (0.42) | POLBGAASLC6A4SLC6A3KMT2A | |
| SCHEMBL7596808 | 0.80 | POLB (0.47) | POLBHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL29229610 | 0.80 | POLB (0.47) | POLBKMT2AMEN1CYP1A2TSHR | |
| SCHEMBL5730818 | 0.80 | L3MBTL1 (0.50) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL4402923 | 0.80 | POLB (0.71) | POLBHDAC3HDAC4HDAC7HDAC8 | |
| SCHEMBL30341829 | 0.80 | POLB (0.71) | POLBHDAC3HDAC4HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103224474-A | Synthesis of tetracyclines and analogues thereof | HARVARD COLLEGE | 2013-07-31 | — | — | CN | claimed |
| CN-101027279-B | Synthesis of tetracyclines and analogues thereof | HARVARD COLLEGE | 2013-03-27 | — | — | CN | claimed |
| WO-2012083261-A1 | BLOOD BRAIN BARRIER-PENETRATING OXIMES FOR CHOLISTENERASES REACTIVATION | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-06-21 | — | — | WO | claimed |
| CN-101796062-A | 6-disubstituted bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC | 2010-08-04 | — | — | CN | claimed |
| CN-101490074-A | 5'-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS INC (US) | 2009-07-22 | — | — | CN | claimed |
| US-20210355154-A1 | Halogenated Cholesterol Analogues and Methods of Making and Using Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2021-11-18 | — | — | US | disclosed |
| US-11117923-B2 | Immune modulatory compositions | RAJAPPAN KUMAR (US) | 2021-09-14 | — | — | US | disclosed |
| EP-3856756-A1 | HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME | The Regents Of The University Of Michigan (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2021093846-A1 | NOVEL TETRACYCLIC HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF | 上海拓界生物医药科技有限公司 | 2021-05-20 | — | — | WO | disclosed |
| WO-2020069267-A1 | HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-04-02 | — | — | WO | disclosed |
| US-20200062799-A1 | IMMUNE MODULATORY COMPOSITIONS | RAJAPPAN KUMAR (US) | 2020-02-27 | — | — | US | disclosed |
| CN-105793262-B | Two cycloalkyne derivatives and application thereof | 新加坡科技研究局 | 2019-09-03 | — | — | CN | disclosed |
| EP-1578734-A1 | NOVEL ANTIBACTERIAL AGENTS | Orchid Chemicals and Pharmaceuticals Ltd (IN) | 2005-09-28 | — | — | EP | disclosed |
| CN-1617865-A | benzyne | ORTHO MCNEIL PHARM INC (US) | 2005-05-18 | — | — | CN | disclosed |
| US-20050070526-A1 | Novel antibacterial agents | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2005-03-31 | — | — | US | disclosed |
| CN-1568190-A | Combination therapy comprising glucose reabsorption inhibitor and PPAR modulator | ORTHO MCNEIL PHARM INC (US) | 2005-01-19 | — | — | CN | disclosed |
| WO-2004018439-A1 | NOVEL ANTIBACTERIAL AGENTS | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2004-03-04 | — | — | WO | disclosed |
| WO-2003093247-A2 | ANTIBACTERIAL AGENTS | ORCHID CHEMICALS & PHARMACEUTICALS LTD (IN) | 2003-11-13 | — | — | WO | disclosed |
| EP-1259492-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES AS MTP INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001047899-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070526-A1 | Novel antibacterial agents | TBCD, OXA1L, ALPI | POLB 881/4885HDAC3 1409/4885HDAC4 678/4885 |
| US-20200062799-A1 | IMMUNE MODULATORY COMPOSITIONS | STING1, IFNAR1, IRF3 | POLB 973/4885HDAC3 4699/4885HDAC4 4442/4885 |
| US-11117923-B2 | Immune modulatory compositions | STING1, IFNAR1, IRF3 | POLB 973/4885HDAC3 4699/4885HDAC4 4442/4885 |
| US-20210355154-A1 | Halogenated Cholesterol Analogues and Methods of Making and Using Same | CYP46A1, DHCR7, CETP | POLB 1161/4885HDAC3 2563/4885HDAC4 4209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.