SCHEMBL7596808

SCHEMBL7596808

CC(C)(C)OC(=O)OC1c2ccccc2-c2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.47
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
NCOR2 Q9Y618 1/20 0.41
ELANE P08246 1/20 0.38
KMT2A Q03164 2/20 0.37
ALDH1A1 P00352 2/20 0.36
HBB P68871 1/20 0.36
HSD17B10 Q99714 1/20 0.36
EDNRB P24530 1/20 0.35
EDNRA P25101 1/20 0.35
GAA P10253 1/20 0.35
CACNA1G O43497 1/20 0.35
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27777776 0.83 POLB (0.53) POLBHDAC3HDAC4HDAC7HDAC8
SCHEMBL7602479 0.82 PKM (0.47) POLBHDAC3HDAC4HDAC7HDAC8
SCHEMBL434649 0.80 POLB (0.52) POLBHDAC3HDAC4HDAC7HDAC8
SCHEMBL18826207 0.79 POLB (0.50) POLBHDAC3HDAC4HDAC7HDAC8
SCHEMBL21778870 0.77 MALT1 (0.44) POLBKMT2AALDH1A1MEN1LMNA
SCHEMBL2542606 0.77 POLB (0.49) POLBHDAC3HDAC4HDAC7HDAC8
SCHEMBL29229610 0.76 POLB (0.47) POLBKMT2AALDH1A1HSD17B10MEN1
SCHEMBL27843761 0.76 POLB (0.47) POLBHDAC3HDAC4HDAC7HDAC8
SCHEMBL26419663 0.76 GPR119 (0.38) POLBELANEKMT2AMEN1BCHE
SCHEMBL30341829 0.76 POLB (0.71) POLBHDAC3HDAC4HDAC7HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874281-B1 Chemically amplified resist INFINEON TECHNOLOGIES AG (DE) 2002-12-04 EP disclosed
EP-0874281-A1 Chemically amplified resist SIEMENS AKTIENGESELLSCHAFT (DE) 1998-10-28 EP disclosed