Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 14/20 | 0.46 |
| ▸ | TAB1 | Q15750 | 14/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350420 | 1.00 | MAP3K7 (0.46) | MAP3K7TAB1BTKCITKMT2A | |
| SCHEMBL4346952 | 0.87 | MAP3K7 (0.43) | MAP3K7TAB1BTK | |
| SCHEMBL4346955 | 0.87 | MAP3K7 (0.43) | MAP3K7TAB1BTK | |
| SCHEMBL16932989 | 0.86 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL16932988 | 0.86 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL4346854 | 0.85 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL4346848 | 0.85 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL13821438 | 0.81 | MAP3K7 (0.41) | MAP3K7TAB1BTK | |
| SCHEMBL4346683 | 0.80 | GSK3B (0.49) | BTK | |
| SCHEMBL4346687 | 0.80 | GSK3B (0.49) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |