Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 11/20 | 0.43 |
| ▸ | TAB1 | Q15750 | 11/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346955 | 1.00 | MAP3K7 (0.43) | MAP3K7TAB1DYRK1ACLK1DYRK2 | |
| SCHEMBL4350414 | 0.87 | MAP3K7 (0.46) | MAP3K7TAB1BTK | |
| SCHEMBL4350420 | 0.87 | MAP3K7 (0.46) | MAP3K7TAB1BTK | |
| SCHEMBL16932989 | 0.86 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL16932988 | 0.86 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL4346854 | 0.84 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL4346848 | 0.84 | MAP3K7 (0.47) | MAP3K7TAB1BTK | |
| SCHEMBL13821438 | 0.83 | MAP3K7 (0.41) | MAP3K7TAB1ABL1BTK | |
| SCHEMBL4835466 | 0.83 | DYRK1A (0.45) | DYRK1ACLK1DYRK2DYRK1BNTRK1 | |
| SCHEMBL4343457 | 0.82 | PRKD3 (0.53) | MAP3K7TAB1DYRK1ACLK1NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |