Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | STAT6 | P42226 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341339 | 0.94 | PYGL (0.39) | PYGLBCAT1CYP51A1DRD2GHSR | |
| SCHEMBL4343217 | 0.94 | POLB (0.47) | PYGLCYP51A1POLBCNR1GHSR | |
| SCHEMBL4343715 | 0.94 | POLB (0.47) | PYGLCYP51A1POLBCNR1GHSR | |
| SCHEMBL19856944 | 0.89 | CYP51A1 (0.38) | PYGLBCAT1CYP51A1DRD2ALOX15 | |
| SCHEMBL4343831 | 0.89 | STAT6 (0.39) | PYGLBCAT1CYP51A1DRD2ALOX15 | |
| SCHEMBL19856939 | 0.89 | CYP51A1 (0.38) | PYGLBCAT1CYP51A1DRD2ALOX15 | |
| SCHEMBL4341295 | 0.88 | POLB (0.41) | PYGLCYP51A1POLBGHSRALOX15 | |
| SCHEMBL4336622 | 0.88 | POLB (0.41) | PYGLCYP51A1POLBGHSRALOX15 | |
| SCHEMBL4338819 | 0.87 | STAT6 (0.40) | PYGLBCAT1CYP51A1POLBDRD2 | |
| SCHEMBL8002404 | 0.86 | PYGL (0.37) | PYGLBCAT1CYP51A1POLBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | claimed |
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |