Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 2/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | CYP51A1 | Q16850 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341295 | 1.00 | POLB (0.41) | POLBGHSRSTAT6CYP51A1ATM | |
| SCHEMBL4343715 | 0.95 | POLB (0.47) | POLBGHSRSTAT6CYP51A1ATM | |
| SCHEMBL4343217 | 0.95 | POLB (0.47) | POLBGHSRSTAT6CYP51A1ATM | |
| SCHEMBL4341339 | 0.94 | PYGL (0.39) | GHSRSTAT6CYP51A1PYGLSMYD3 | |
| SCHEMBL4347129 | 0.88 | PYGL (0.39) | POLBGHSRSTAT6CYP51A1PYGL | |
| SCHEMBL4350448 | 0.87 | STAT6 (0.40) | POLBSTAT6CYP51A1PYGLSMYD3 | |
| SCHEMBL4340949 | 0.87 | STAT6 (0.39) | STAT6CYP51A1PYGLSMYD3ALOX15 | |
| SCHEMBL4350449 | 0.83 | HTRA1 (0.36) | POLBSTAT6CYP51A1PYGLSMYD3 | |
| SCHEMBL4341332 | 0.83 | HTRA1 (0.36) | POLBSTAT6CYP51A1PYGLSMYD3 | |
| SCHEMBL19856968 | 0.83 | CCKBR (0.44) | STAT6CYP51A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | claimed |
| WO-2009146182-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |