Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 18/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 18/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 18/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.45 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348370 | 1.00 | HDAC3 (0.45) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4348278 | 0.86 | GSK3B (0.52) | HDAC1HDAC6 | |
| SCHEMBL4348275 | 0.86 | GSK3B (0.52) | HDAC1HDAC6 | |
| Hydrochloric Acid SCHEMBL4357449 | 0.86 | AKT1 (0.46) | HDAC1HDAC6ITGB2ICAM1ITGAL | |
| Hydrochloric Acid SCHEMBL4343253 | 0.86 | KMT2A (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL4357444 | 0.86 | AKT1 (0.46) | HDAC1HDAC6ITGB2ICAM1ITGAL | |
| Hydrochloric Acid SCHEMBL4346899 | 0.86 | LMNA (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL4346903 | 0.86 | LMNA (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL4343259 | 0.86 | KMT2A (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL4348323 | 0.85 | GSK3B (0.51) | HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |