Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4351418 | 0.87 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL14433842 | 0.84 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL4346126 | 0.84 | LMNA (0.61) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL27782816 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL10662740 | 0.82 | LMNA (0.67) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL4350358 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL4347034 | 0.82 | EPHX2 (0.67) | KMT2AHTTMEN1EPHX2MAPT | |
| SCHEMBL4354051 | 0.82 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL4350868 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAHPGDGAAKMT2A | |
| SCHEMBL8602435 | 0.81 | EPHX2 (0.69) | KMT2AHTTMEN1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |