Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348477 | 1.00 | KMT2A (0.46) | KMT2AAKT1GSK3BJAK3CHEK1 | |
| SCHEMBL4343997 | 0.86 | KMT2A (0.50) | KMT2AAKT1GSK3BCHEK1CDC7 | |
| SCHEMBL4354582 | 0.86 | KMT2A (0.50) | KMT2AAKT1GSK3BCHEK1CDC7 | |
| SCHEMBL4343641 | 0.84 | TDP1 (0.54) | KMT2AGSK3BCDC7MAP2K1 | |
| SCHEMBL4343650 | 0.84 | TDP1 (0.54) | KMT2AGSK3BCDC7MAP2K1 | |
| SCHEMBL4513050 | 0.84 | AKT1 (0.56) | KMT2AAKT1GSK3BJAK3CHEK1 | |
| SCHEMBL4513046 | 0.84 | AKT1 (0.56) | KMT2AAKT1GSK3BJAK3CHEK1 | |
| SCHEMBL4513055 | 0.84 | AKT1 (0.56) | KMT2AAKT1GSK3BJAK3CHEK1 | |
| SCHEMBL4352465 | 0.82 | KMT2A (0.45) | KMT2AAKT1GSK3BJAK3CHEK1 | |
| SCHEMBL4352472 | 0.82 | KMT2A (0.45) | KMT2AAKT1GSK3BJAK3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |