Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4352472 | 1.00 | KMT2A (0.45) | KMT2ACHEK1LRRK2GSK3BAKT1 | |
| SCHEMBL4343997 | 0.85 | KMT2A (0.50) | KMT2ACHEK1GSK3BAKT1CDC7 | |
| SCHEMBL4354582 | 0.85 | KMT2A (0.50) | KMT2ACHEK1GSK3BAKT1CDC7 | |
| SCHEMBL4343641 | 0.84 | TDP1 (0.54) | KMT2AGSK3BCDC7CDK2DYRK1A | |
| SCHEMBL4343650 | 0.84 | TDP1 (0.54) | KMT2AGSK3BCDC7CDK2DYRK1A | |
| SCHEMBL24759210 | 0.83 | CHEK1 (0.48) | KMT2ACHEK1GSK3BNEK2ROCK2 | |
| SCHEMBL4348477 | 0.82 | KMT2A (0.46) | KMT2ACHEK1GSK3BAKT1CDC7 | |
| SCHEMBL4348485 | 0.82 | KMT2A (0.46) | KMT2ACHEK1GSK3BAKT1CDC7 | |
| SCHEMBL4513055 | 0.81 | AKT1 (0.56) | KMT2ACHEK1GSK3BAKT1NEK2 | |
| SCHEMBL4513050 | 0.81 | AKT1 (0.56) | KMT2ACHEK1GSK3BAKT1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |