SCHEMBL4348658

SCHEMBL4348658

C/C(=C(\F)C(=O)Nc1ccc(-c2ccccc2S(N)(=O)=O)cc1Br)c1cccc(C(=N)NO)c1

nearest known ligand 0.85

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.85
F2 P00734 5/20 0.85
PRSS1 P07477 5/20 0.85
KCNH2 Q12809 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4352256 0.80 F10 (1.00) F10F2PRSS1
SCHEMBL4352253 0.80 F10 (1.00) F10F2PRSS1
SCHEMBL7688293 0.79 F10 (1.00) F10F2PRSS1KCNH2
SCHEMBL7690621 0.79 F10 (1.00) F10F2PRSS1KCNH2
SCHEMBL4096654 0.77 F10 (0.62) F10F2PRSS1
SCHEMBL4096651 0.77 F10 (0.62) F10F2PRSS1
SCHEMBL7684143 0.76 F10 (1.00) F10F2PRSS1KCNH2
SCHEMBL7684142 0.76 F10 (1.00) F10F2PRSS1KCNH2
SCHEMBL7690881 0.71 F10 (1.00) F10F2PRSS1
SCHEMBL7690879 0.71 F10 (1.00) F10F2PRSS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090285887-A1 Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor GLAXO GROUP LIMITED (GB) 2009-11-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090285887-A1 Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor F12, TFPI, PLAT F10 11/4885F2 10/4885PRSS1 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.