Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | NT5E | P21589 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776182 | 1.00 | LMNA (0.70) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL2779773 | 1.00 | LMNA (0.70) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL2774718 | 0.91 | LMNA (0.72) | LMNANT5EHIF1AADORA2AADORA2B | |
| SCHEMBL2778969 | 0.86 | LMNA (0.65) | LMNANT5EHIF1AADORA2AADORA2B | |
| Fludarabine SCHEMBL13046076 | 0.83 | LMNA (1.00) | LMNANT5EHIF1AADORA2AADORA2B | |
| Fludarabine SCHEMBL12018219 | 0.83 | LMNA (1.00) | LMNANT5EHIF1AADORA2AADORA2B | |
| Fludarabine SCHEMBL977919 | 0.83 | LMNA (1.00) | LMNANT5EHIF1AADORA2AADORA2B | |
| Fludarabine SCHEMBL13046078 | 0.83 | LMNA (1.00) | LMNANT5EHIF1AADORA2AADORA2B | |
| Fludarabine SCHEMBL14031844 | 0.83 | LMNA (1.00) | LMNANT5EHIF1AADORA2AADORA2B | |
| Fludarabine SCHEMBL12232219 | 0.83 | LMNA (1.00) | LMNANT5EHIF1AADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081946-A2 | ADENOSINE DERIVATIVES FOR THE TREATMENT OF PAIN | Biovitrum AB (publ) (SE) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008000745-A2 | ADENOSINE DERIVATIVES FOR THE TREATMENT OF PAIN | BIOVITRUM AB (PUBL) (SE) | 2008-01-03 | — | — | WO | disclosed |