Fludarabine

Fludarabine

SCHEMBL977919

Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 1.00
NT5E P21589 1/20 1.00
HIF1A Q16665 1/20 1.00
ADORA2A P29274 7/20 0.73
ADORA2B P29275 5/20 0.73
ADORA3 P0DMS8 3/20 0.71
CA5A P35218 1/20 0.70
ADORA1 P30542 2/20 0.69
DPP4 P27487 1/20 0.69
MEN1 O00255 1/20 0.69
SLC28A1 O00337 1/20 0.69
MAP3K7 O43318 1/20 0.69
SLC28A2 O43868 1/20 0.69
GAPDH P04406 1/20 0.69
MAPK1 P28482 1/20 0.69
STAT6 P42226 1/20 0.69
PI4KA P42356 1/20 0.69
KMT2A Q03164 1/20 0.69
SMN1; SMN2 Q16637 1/20 0.69
PI4K2B Q8TCG2 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fludarabine SCHEMBL3047091 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL12018219 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL12018226 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL3655059 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL13046076 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL12232219 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL13046078 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL14031844 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL12019517 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B
Fludarabine SCHEMBL1981701 1.00 LMNA (1.00) LMNANT5EHIF1AADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 949 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
WO-2026102302-A1 POLYNUCLEOTIDES CONTAINING A MODIFIED 3'-REGION MODERNATX, INC. (US) 2026-05-15 WO claimed
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2024-05-02 US claimed
CN-117858949-A RNAi agents for inhibiting expression of mucin 5AC (MUC 5 AC), compositions thereof, and methods of use thereof 箭头药业股份有限公司 2024-04-09 CN claimed
CN-117467726-A Preparation method of purine nucleoside 天津凯莱英生物科技有限公司 2024-01-30 CN claimed
CN-117440817-A RNAi agents for inhibiting expression of advanced glycation end product receptors, compositions and methods of use thereof 箭头药业股份有限公司 2024-01-23 CN claimed
CN-116801885-A RNAi agents for inhibiting DUX4 expression, compositions and methods of use 箭头药业股份有限公司 2023-09-22 CN claimed
US-11553713-B2 Polyalcohol, carbohydrate, nucleobase and nucleotide compositions and uses thereof Zhang, Chunbo (US) 2023-01-17 US claimed
CN-113549076-B Polysubstituted purine compound and preparation method and application thereof 中国药科大学 2022-12-06 CN claimed
EP-4045504-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS Ai-biopharma (FR) 2022-08-24 EP claimed
US-6372725-B1 VIRICIDES, ANTICARCINOGENIC AND ANTITUMOR AGENTS; SIDE EFFECT REDUCTION HEIDELBERG PHARMA HOLDING GMBH (DE) 2002-04-16 US claimed
EP-0817790-B1 SPECIFIC LIPID CONJUGATES OF NUCLEOSIDE DIPHOSPHATES AND THEIR USE AS DRUGS HEIDELBERG PHARMA HOLDING GMBH (DE) 2001-11-14 EP claimed
US-6025343-A Lipid esters of nucleoside monophosphates and their use as immunosuppressive drugs ROCHE DIAGNOSTICS GMBH (DE) 2000-02-15 US claimed
US-6017896-A Purine nucleoside phosphorylase gene therapy for human malignancy UNIVERSITY OF ALABAMA RESEARCH FOUNDATION AND SOUTHERN RESEARCH INSTITUTE (US) 2000-01-25 US claimed
EP-0670845-B1 PROCESS FOR THE PREPARATION OF FLUDARABINE PHOSPHATE FROM GUANOSINE SCHERING AG (DE) 1998-01-14 EP claimed
US-5696255-A Process for the production of 2-fluoropurine derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1997-12-09 US claimed
US-5602246-A Process for the preparation of fludarabine or fludarabine phosphate from guanosine SCHERING AKTIENGESELLSCHAFT (DE) 1997-02-11 US claimed
EP-0670845-A1 PROCESS FOR THE PREPARATION OF FLUDARABINE PHOSPHATE FROM GUANOSINE SCHERING AKTIENGESELLSCHAFT (DE) 1995-09-13 EP claimed
WO-1994012514-A1 PROCESS FOR THE PREPARATION OF FLUDARABINE PHOSPHATE FROM GUANOSINE SCHERING AKTIENGESELLSCHAFT (DE) 1994-06-09 WO claimed
US-4751224-A FORSKOLIN DERIVATIVES; ANTIAGGLOMERANTS BROWN UNIVERSITY RESEARCH FOUNDATION (US) 1988-06-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 LMNA 1661/4885NT5E 1487/4885HIF1A 3160/4885
US-11553713-B2 Polyalcohol, carbohydrate, nucleobase and nucleotide compositions and uses thereof PNP, RNMT, RNGTT LMNA 989/4885NT5E 19/4885HIF1A 4735/4885
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS SLC10A1, HAVCR2, HDGF LMNA 2736/4885NT5E 4039/4885HIF1A 3038/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.