SCHEMBL4349259

SCHEMBL4349259

C=CC(=O)NCCC[Si](C)(C)O[Si](C)(C)CCCNC(=O)C=C

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ZDHHC20 Q5W0Z9 1/20 0.55
ZDHHC2 Q9UIJ5 1/20 0.55
TSHR P16473 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MAPK1 P28482 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
GAA P10253 1/20 0.43
TGM2 P21980 10/20 0.40
KMT5A Q9NQR1 1/20 0.36
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.33
ATM Q13315 1/20 0.33
MTNR1A P48039 1/20 0.31
MTNR1B P49286 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18176149 0.93 ZDHHC20 (0.62) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL27428987 0.89 ZDHHC20 (0.47) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL9067237 0.87 ZDHHC20 (0.53) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL27055198 0.86 ZDHHC20 (0.57) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL6276037 0.85 ZDHHC20 (0.58) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL13051865 0.84 ZDHHC20 (0.50) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL31351451 0.84 ZDHHC20 (0.54) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL851109 0.84 ZDHHC20 (0.54) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL7783113 0.83 ZDHHC20 (0.56) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1
SCHEMBL28413988 0.83 ZDHHC20 (0.49) ZDHHC20ZDHHC2TSHRALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4514597-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES Alcon Inc. (CH) 2025-03-05 EP claimed
US-20230364832-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES ALCON INC. (CH) 2023-11-16 US claimed
WO-2023209631-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES ALCON INC. (CH) 2023-11-02 WO claimed
EP-2764065-B1 SACRIFICIAL ADHESIVE COATINGS ROCHAL IND LLC (US) 2017-03-22 EP claimed
US-9568645-B2 Silicone hydrogel lenses with relatively-long thermal stability NOVARTIS AG (CH) 2017-02-14 US claimed
EP-3052535-A1 SILICONE HYDROGEL LENSES WITH RELATIVELY-LONG THERMAL STABILITY Novartis AG (CH) 2016-08-10 EP claimed
WO-2015048279-A1 SILICONE HYDROGEL LENSES WITH RELATIVELY-LONG THERMAL STABILITY NOVARTIS AG (CH) 2015-04-02 WO claimed
US-20150092155-A1 SILICONE HYDROGEL LENSES WITH RELATIVELY-LONG THERMAL STABILITY ALCON INC. (CH) 2015-04-02 US claimed
US-8263720-B1 Sacrificial adhesive coatings ROCHAL INDUSTRIES, LLP (US) 2012-09-11 US claimed
EP-4514597-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES Alcon Inc. (CH) 2025-03-05 EP disclosed
US-20230364832-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES ALCON INC. (CH) 2023-11-16 US disclosed
WO-2023209631-A1 METHOD FOR MAKING UV AND HEVL-ABSORBING OPHTHALMIC LENSES ALCON INC. (CH) 2023-11-02 WO disclosed
EP-3197940-B1 POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS ALCON INC (CH) 2023-02-15 EP disclosed
EP-3052534-B1 METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES NOVARTIS AG (CH) 2019-05-01 EP disclosed
US-7566754-B2 Process for making contact lenses from prepolymers NOVARTIS AG (CH) 2009-07-28 US disclosed
EP-1956033-B1 Acrylimides with initiator characteristics MONDI RELEASE LINER AUSTRIA GM (AT) 2009-05-06 EP disclosed
EP-1956033-A1 Acrylimides with initiator characteristics Mondi Release Liner Austria GmbH (AT) 2008-08-13 EP disclosed
US-20080021127-A1 Novel polymers ALCON INC. (CH) 2008-01-24 US disclosed
US-7268189-B2 Polymers NOVARTIS AG (CH) 2007-09-11 US disclosed
US-7238750-B2 Polymers NOVARTIS AG (CH) 2007-07-03 US disclosed