Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6557730 | 0.65 | NPC1 (0.49) | POLBSMN1; SMN2NPC1RAB9AP2RX7 | |
| SCHEMBL14790527 | 0.65 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AP2RX7 | |
| SCHEMBL14711447 | 0.65 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AP2RX7 | |
| SCHEMBL6556281 | 0.64 | NPC1 (0.46) | POLBSMN1; SMN2NPC1RAB9AMAOB | |
| SCHEMBL4759503 | 0.64 | SMN1; SMN2 (0.57) | POLBSMN1; SMN2NPC1RAB9AMGLL | |
| SCHEMBL6556294 | 0.64 | NPC1 (0.47) | POLBSMN1; SMN2NPC1RAB9AP2RX7 | |
| SCHEMBL590420 | 0.63 | POLB (0.62) | POLBSMN1; SMN2NPC1RAB9AMAPKAPK2 | |
| SCHEMBL27415197 | 0.62 | SMN1; SMN2 (0.55) | POLBSMN1; SMN2NPC1RAB9AMGLL | |
| SCHEMBL1568055 | 0.62 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL27467966 | 0.61 | NPC1 (0.50) | POLBSMN1; SMN2NPC1RAB9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197949-A1 | ANTITUMOR METHODS AND COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES | F.P.L. PHARMA, INC. (CA) | 2009-08-06 | — | — | US | disclosed |
| EP-1706376-B1 | IMIDAZOLE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA SA (BE) | 2009-03-04 | — | — | EP | disclosed |
| US-20040191342-A1 | Antitumor methods and compositions comprising sesquiterpene derivatives | F.P.L. PHARMA INC. (CA) | 2004-09-30 | — | — | US | disclosed |
| EP-1372677-A1 | ANTITUMOR METHODS AND COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES | F.P.L. Pharma Inc. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002078719-A1 | ANTITUMOR METHODS AND COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES | F.P.L. PHARMA INC. (CA) | 2002-10-10 | — | — | WO | disclosed |