Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353056 | 1.00 | KDM4E (0.40) | KDM4ECYP2D6TSHRHIF1AHDAC3 | |
| SCHEMBL4350005 | 0.88 | GSK3B (0.47) | HDAC1HDAC6KMT2AMAPTTP53 | |
| SCHEMBL4355315 | 0.88 | GSK3B (0.47) | HDAC1HDAC6KMT2AMAPTTP53 | |
| SCHEMBL4355310 | 0.88 | GSK3B (0.47) | HDAC1HDAC6KMT2AMAPTTP53 | |
| SCHEMBL4349997 | 0.88 | GSK3B (0.47) | HDAC1HDAC6KMT2AMAPTTP53 | |
| SCHEMBL4350430 | 0.85 | KMT2A (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4350437 | 0.85 | KMT2A (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4350717 | 0.85 | AURKA (0.46) | HDAC1HDAC6KMT2ATP53DRD4 | |
| SCHEMBL4350722 | 0.85 | AURKA (0.46) | HDAC1HDAC6KMT2ATP53DRD4 | |
| SCHEMBL4355953 | 0.84 | DYRK1A (0.44) | KMT2AMAPK1MAPTTP53DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |