SCHEMBL4350425

SCHEMBL4350425

CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2ccccc2CN)c(F)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 1.00
F2 P00734 11/20 1.00
PRSS1 P07477 6/20 0.87
PROC P04070 3/20 0.87
KLKB1 P03952 2/20 0.87
PRSS2 P07478 5/20 0.75
PRSS3 P35030 5/20 0.75
F9 P00740 2/20 0.75
KLK1 P06870 1/20 0.75
CFH P08603 1/20 0.74
CARM1 Q86X55 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14318599 0.93 F10 (1.00) F10F2PRSS1PROCKLKB1
SCHEMBL8163627 0.87 F10 (0.80) F10F2PRSS1PROCKLKB1
SCHEMBL3052253 0.86 F10 (1.00) F10F2PRSS1PROCKLKB1
SCHEMBL29825652 0.86 F10 (1.00) F10F2PRSS1PROCKLKB1
SCHEMBL31067656 0.86 F10 (1.00) F10F2PRSS1PROCKLKB1
Hydrochloric Acid SCHEMBL29377504 0.85 F10 (1.00) F10F2PRSS1PROCKLKB1
SCHEMBL14176283 0.82 F10 (0.80) F10F2PRSS1PROCKLKB1
SCHEMBL5097161 0.82 F10 (0.79) F10F2PRSS1PROCKLKB1
SCHEMBL5100150 0.82 F10 (0.79) F10F2PRSS1PROCKLKB1
SCHEMBL8165499 0.80 F10 (0.81) F10F2PRSS1PROCKLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090285887-A1 Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor GLAXO GROUP LIMITED (GB) 2009-11-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090285887-A1 Pharmaceutical Composition Comprising A Plurality of Mini-Tablets Comprising A Factor XA Inhibitor F12, TFPI, PLAT F10 11/4885F2 10/4885PRSS1 79/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.