Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350437 | 1.00 | KMT2A (0.42) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4348278 | 0.86 | GSK3B (0.52) | KMT2AHDAC1HDAC6AKT1GSK3B | |
| SCHEMBL4348275 | 0.86 | GSK3B (0.52) | KMT2AHDAC1HDAC6AKT1GSK3B | |
| SCHEMBL4353050 | 0.85 | KDM4E (0.40) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4353056 | 0.85 | KDM4E (0.40) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL4348331 | 0.85 | GSK3B (0.51) | KMT2AHDAC1HDAC6AKT1GSK3B | |
| Hydrochloric Acid SCHEMBL4348323 | 0.85 | GSK3B (0.51) | KMT2AHDAC1HDAC6AKT1GSK3B | |
| Hydrochloric Acid SCHEMBL4351327 | 0.83 | GSK3B (0.43) | KMT2AHDAC1HDAC6AKT1GSK3B | |
| Hydrochloric Acid SCHEMBL4351321 | 0.83 | GSK3B (0.43) | KMT2AHDAC1HDAC6AKT1GSK3B | |
| SCHEMBL4358930 | 0.83 | AURKA (0.53) | KMT2AHDAC1HDAC6AKT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |