SCHEMBL4350448

CC(C)(C)[C@H](NC(=O)c1cc2ccccc2[nH]1)C(=O)N1C[C@@H]2C[C@H]1CN2C(=O)[C@H]1CCCCN1S(=O)(=O)c1ccc(Cl)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	STAT6	P42226	1/20	0.40

▸	HTRA1	Q92743	2/20	0.37

▸	CYP51A1	Q16850	7/20	0.37

▸	PYGL	P06737	2/20	0.36

▸	SMYD3	Q9H7B4	1/20	0.36

▸	DRD3	P35462	2/20	0.35

▸	ALOX15	P16050	1/20	0.35

▸	CCKBR	P32239	1/20	0.34

▸	DRD2	P14416	1/20	0.34

▸	POLB	P06746	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4340949	0.96	STAT6 (0.39)	STAT6HTRA1CYP51A1PYGLSMYD3
SCHEMBL4338819	0.95	STAT6 (0.40)	STAT6HTRA1CYP51A1PYGLSMYD3
SCHEMBL4343831	0.90	STAT6 (0.39)	STAT6HTRA1CYP51A1PYGLSMYD3
SCHEMBL4350449	0.90	HTRA1 (0.36)	STAT6HTRA1CYP51A1PYGLSMYD3
SCHEMBL4341332	0.90	HTRA1 (0.36)	STAT6HTRA1CYP51A1PYGLSMYD3
SCHEMBL4341339	0.87	PYGL (0.39)	STAT6CYP51A1PYGLSMYD3DRD3
SCHEMBL4336622	0.87	POLB (0.41)	STAT6CYP51A1PYGLSMYD3DRD3
SCHEMBL4341295	0.87	POLB (0.41)	STAT6CYP51A1PYGLSMYD3DRD3
SCHEMBL7996254	0.86	STAT6 (0.37)	STAT6HTRA1CYP51A1PYGLSMYD3
SCHEMBL19856944	0.85	CYP51A1 (0.38)	STAT6HTRA1CYP51A1PYGLSMYD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009146182-A1	TRPV4 ANTAGONISTS	SMITHKLINE BEECHAM CORPORATION (US)	2009-12-03	—	—	WO	claimed
WO-2009146182-A1	TRPV4 ANTAGONISTS	SMITHKLINE BEECHAM CORPORATION (US)	2009-12-03	—	—	WO	disclosed