SCHEMBL435046

SCHEMBL435046

CCC[Si](C)(C)OC(C)=O

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.36
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.36
PAOX Q6QHF9 1/20 0.31
FAAH O00519 1/20 0.31
TSHR P16473 2/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL704202 0.87 ALDH1A1 (0.35) ALDH1A1LMNAHSD17B10TSHR
SCHEMBL476046 0.86 ALDH1A1 (0.43) ALDH1A1LMNAHSD17B10PAOXFAAH
SCHEMBL475984 0.84 ALDH1A1 (0.41) ALDH1A1FAAHTSHR
SCHEMBL476010 0.82 FAAH (0.42) ALDH1A1HSD17B10FAAHTSHRTDP1
SCHEMBL475849 0.82 FAAH (0.42) ALDH1A1HSD17B10FAAHTSHRTDP1
SCHEMBL475988 0.82 FAAH (0.42) ALDH1A1HSD17B10FAAHTSHRTDP1
SCHEMBL475913 0.82 FAAH (0.42) ALDH1A1HSD17B10FAAHTSHRTDP1
SCHEMBL476208 0.82 FAAH (0.42) ALDH1A1HSD17B10FAAHTSHRTDP1
SCHEMBL705061 0.82 KDM4E (0.35) ALDH1A1LMNAHSD17B10TSHR
SCHEMBL712067 0.82 KDM4E (0.35) ALDH1A1LMNAHSD17B10TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3281941-B1 PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID ZENTIVA KS (CZ) 2019-07-24 EP claimed
EP-3281941-A1 PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID Zentiva K.S. (CZ) 2018-02-14 EP claimed
EP-0700926-B1 Process for the preparation of gestodene IND CHIMICA SRL (IT) 1998-11-04 EP claimed
EP-3281941-B1 PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID ZENTIVA KS (CZ) 2019-07-24 EP disclosed
EP-3281941-A1 PROCESS FOR PREPARING 2-(5-BROMO-4-(1-CYCLOPROPYLNAPHTHALEN-4-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETIC ACID Zentiva K.S. (CZ) 2018-02-14 EP disclosed
EP-2912120-B1 ANTIFOULING COATING COMPOSITION JOTUN AS (NO) 2017-12-20 EP disclosed
CN-106200270-A Photosensitive resin composition for color filter and application thereof 奇美实业股份有限公司 2016-12-07 CN disclosed
EP-2725073-B1 Antifouling coating composition JOTUN AS (NO) 2016-08-03 EP disclosed
CN-105629660-A Photosensitive resin composition for black matrix and application thereof CHI MEI CORP 2016-06-01 CN disclosed
US-9212136-B2 Methods for producing paricalcitol AZAD PHARMACEUTICALS INGREDIENTS AG (CH) 2015-12-15 US disclosed
EP-2912120-A1 ANTIFOULING COATING COMPOSITION Jotun A/S (NO) 2015-09-02 EP disclosed
EP-2318416-A1 SPIROAMINODIHYDROTHIAZINE DERIVATIVES Eisai R&D Management Co., Ltd. (JP) 2011-05-11 EP disclosed
EP-2294148-A1 BINDER FOR ANTIFOULING COATING COMPOSITION AND ANTIFOULING COATING COMPOSITION COMPRISING BINDER Jotun A/S (NO) 2011-03-16 EP disclosed
EP-2173780-A1 BRANCHED POLYMER AND ANTIFOULING COATING COMPOSITION COMPRISING THE POLYMER Jotun A/S (NO) 2010-04-14 EP disclosed
WO-2009149919-A1 BINDER FOR ANTIFOULING COATING COMPOSITION AND ANTIFOULING COATING COMPOSITION COMPRISING BINDER JOTUN A/S (NO) 2009-12-17 WO disclosed
WO-2009007276-A1 BRANCHED POLYMER AND ANTIFOULING COATING COMPOSITION COMPRISING THE POLYMER JOTUN A/S (NO) 2009-01-15 WO disclosed
US-6011112-A SILYLATED ORGANONITROGEN COMPOUNDS WACKER-CHEMIE GMBH (DE) 2000-01-04 US disclosed
US-5196477-A Protective coating for metal contactor in electronic circuits SHIN-ETSU CHEMICAL CO., LTD. (JP) 1993-03-23 US disclosed
EP-0500621-A1 CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS Pfizer Limited (GB) 1992-09-02 EP disclosed
WO-1991007378-A1 CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS PFIZER LIMITED (GB) 1991-05-30 WO disclosed