Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.60 |
| ▸ | CDK8 | P49336 | 6/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28268292 | 0.82 | CDK8 (0.70) | ROCK2CDK8ROCK1PKN2MAP4K4 | |
| SCHEMBL3502492 | 0.81 | ROCK2 (0.63) | ROCK2POLBROCK1PKN2JAK2 | |
| SCHEMBL1370777 | 0.81 | CDK8 (0.56) | ROCK2CDK8EPHX2NPC1RAB9A | |
| SCHEMBL3499511 | 0.80 | KIT (0.61) | ROCK2CDK8ROCK1PKN2MAP4K4 | |
| SCHEMBL29429732 | 0.80 | KDR (0.63) | ROCK2CDK8HDAC6NPC1RAB9A | |
| SCHEMBL4128043 | 0.80 | KDR (0.63) | ROCK2CDK8HDAC6NPC1RAB9A | |
| SCHEMBL28188767 | 0.80 | HDAC1 (0.67) | EPHX2MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL16085415 | 0.79 | BTK (0.65) | ROCK2CDK8KMT2AROCK1PKN2 | |
| SCHEMBL12969365 | 0.78 | ROCK2 (0.70) | ROCK2EPHX2L3MBTL1NAMPTMEN1 | |
| SCHEMBL896506 | 0.76 | KIT (0.49) | CDK8MEN1KMT2AHSD17B10AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |