Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.66 |
| ▸ | REN | P00797 | 19/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663978 | 0.96 | CYP3A4 (0.67) | CYP3A4RENKCNH2 | |
| SCHEMBL664889 | 0.92 | CYP3A4 (0.79) | CYP3A4RENKCNH2 | |
| SCHEMBL4347867 | 0.91 | CYP3A4 (0.68) | CYP3A4RENKCNH2 | |
| SCHEMBL5069415 | 0.90 | CYP3A4 (0.64) | CYP3A4RENKCNH2 | |
| SCHEMBL4349317 | 0.90 | CYP3A4 (0.66) | CYP3A4RENKCNH2 | |
| SCHEMBL664275 | 0.89 | CYP3A4 (0.65) | CYP3A4RENKCNH2 | |
| SCHEMBL668325 | 0.88 | CYP3A4 (0.64) | CYP3A4RENKCNH2 | |
| SCHEMBL4353647 | 0.88 | REN (0.56) | CYP3A4REN | |
| SCHEMBL664020 | 0.87 | CYP3A4 (0.80) | CYP3A4RENKCNH2 | |
| SCHEMBL664368 | 0.87 | CYP3A4 (0.71) | CYP3A4RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | CYP3A4 531/4885REN 1/4885KCNH2 1536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.