Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 10/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434788 | 0.83 | METAP2 (0.54) | METAP2KCNH2ACLYSIRT6KMT2A | |
| SCHEMBL461132 | 0.82 | METAP2 (0.58) | METAP2KCNH2 | |
| SCHEMBL435387 | 0.82 | METAP2 (0.53) | METAP2KCNH2ACLYSIRT6 | |
| SCHEMBL27918194 | 0.77 | METAP2 (0.58) | METAP2KCNH2ACLYKMT2A | |
| SCHEMBL434122 | 0.77 | METAP2 (0.51) | METAP2KCNH2ACLYSIRT6GAA | |
| SCHEMBL435843 | 0.75 | METAP2 (0.51) | METAP2KCNH2ACLYPIK3CAMAPT | |
| SCHEMBL433893 | 0.74 | METAP2 (0.49) | METAP2KCNH2ACLYKMT2ACMA1 | |
| SCHEMBL15130176 | 0.73 | METAP2 (0.47) | METAP2KCNH2ACLYPIK3CAGAA | |
| SCHEMBL17614631 | 0.73 | METAP2 (0.47) | METAP2KCNH2ACLYSIRT6KMT2A | |
| SCHEMBL15626718 | 0.73 | METAP2 (0.47) | METAP2KCNH2ACLYSIRT6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595988-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | Zafgen, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012642-A1 | TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2012-01-26 | — | — | WO | disclosed |