Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 9/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268545 | 0.88 | MAPT (0.48) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2957394 | 0.88 | MAPT (0.48) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2954152 | 0.87 | NPC1 (0.42) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL8267136 | 0.87 | NPC1 (0.42) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL8267303 | 0.87 | MAPT (0.42) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2951982 | 0.87 | MAPT (0.42) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL5066806 | 0.87 | MAPT (0.45) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL13239409 | 0.85 | RECQL (0.43) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL8268543 | 0.82 | MAPT (0.48) | MAPTKMT2AMEN1NPC1LMNA | |
| SCHEMBL2952209 | 0.82 | MAPT (0.48) | MAPTKMT2AMEN1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809296-A4 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-11 | — | — | EP | disclosed |
| EP-1809296-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006049984-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |