Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954152 | 1.00 | NPC1 (0.42) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4351692 | 0.87 | MAPT (0.42) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL2957394 | 0.86 | MAPT (0.48) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL8268545 | 0.86 | MAPT (0.48) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL2954173 | 0.85 | AVPR2 (0.41) | AVPR2AVPR1A | |
| SCHEMBL8266750 | 0.85 | AVPR2 (0.41) | AVPR2AVPR1A | |
| SCHEMBL2954169 | 0.84 | AVPR2 (0.40) | AVPR2AVPR1A | |
| SCHEMBL13239409 | 0.83 | RECQL (0.43) | NPC1MAPTKMT2AMEN1LMNA | |
| SCHEMBL8268543 | 0.81 | MAPT (0.48) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL2952209 | 0.81 | MAPT (0.48) | NPC1RAB9AMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |
| WO-2006049984-A2 | NOVEL [1,4]BENZODIAZEPINES AS VASOPRESSIN V2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-11 | — | — | WO | disclosed |