Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239411 | 0.91 | RECQL (0.42) | RECQLMAPTKMT2AMEN1LMNA | |
| SCHEMBL8268545 | 0.87 | MAPT (0.48) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL2957394 | 0.87 | MAPT (0.48) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL13239413 | 0.86 | LMNA (0.40) | LMNASMN1; SMN2AVPR2 | |
| SCHEMBL2961930 | 0.86 | LMNA (0.40) | LMNASMN1; SMN2AVPR2 | |
| SCHEMBL2961925 | 0.85 | HSD17B3 (0.40) | LMNASMN1; SMN2AVPR2 | |
| SCHEMBL4351692 | 0.85 | MAPT (0.42) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL2954152 | 0.83 | NPC1 (0.42) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL8267136 | 0.83 | NPC1 (0.42) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL8268543 | 0.82 | MAPT (0.48) | MAPTKMT2AMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763605-B2 | [1,4]benzodiazepines as vasopressin V2 receptor antagonists | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-07-27 | — | — | US | disclosed |