Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | ACACA | Q13085 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357290 | 0.92 | HRH3 (0.44) | HRH3USP2ACACBACACA | |
| SCHEMBL4565355 | 0.89 | HRH3 (0.40) | HRH3USP2SYKACACBACACA | |
| SCHEMBL4353281 | 0.87 | F10 (0.45) | HRH3USP2KDM4EALDH1A1MEN1 | |
| SCHEMBL4364137 | 0.85 | HRH3 (0.39) | HRH3USP2SYKALDH1A1MEN1 | |
| SCHEMBL4365848 | 0.85 | HRH3 (0.43) | HRH3USP2SIGMAR1ACACBACACA | |
| SCHEMBL4355839 | 0.83 | HRH3 (0.43) | HRH3USP2SIGMAR1ACACBACACA | |
| SCHEMBL4539135 | 0.80 | HRH3 (0.54) | HRH3ACACBACACA | |
| SCHEMBL3538363 | 0.77 | HRH3 (0.51) | HRH3USP2KDM4EALDH1A1 | |
| SCHEMBL5133352 | 0.72 | HCRTR2 (0.38) | HRH3 | |
| SCHEMBL27739844 | 0.70 | HRH3 (0.50) | HRH3USP2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |