Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4353281 | 0.87 | F10 (0.45) | HRH3HCRTR2USP2F10MEN1 | |
| SCHEMBL4352105 | 0.85 | HRH3 (0.43) | HRH3SYKUSP2MEN1ALDH1A1 | |
| SCHEMBL4357290 | 0.84 | HRH3 (0.44) | HRH3USP2 | |
| SCHEMBL4565355 | 0.84 | HRH3 (0.40) | HRH3SYKUSP2 | |
| SCHEMBL4355839 | 0.83 | HRH3 (0.43) | HRH3USP2 | |
| SCHEMBL4365848 | 0.81 | HRH3 (0.43) | HRH3USP2ALDH1A1KCNH2 | |
| SCHEMBL3541616 | 0.80 | HRH3 (0.50) | HRH3ALDH1A1HPGDKCNH2 | |
| SCHEMBL4539135 | 0.79 | HRH3 (0.54) | HRH3 | |
| SCHEMBL5133352 | 0.75 | HCRTR2 (0.38) | HRH3HCRTR2 | |
| SCHEMBL5058625 | 0.71 | HRH3 (0.35) | HRH3SYKUSP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |