Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355839 | 0.98 | HRH3 (0.43) | HRH3CYP2D6SIGMAR1PROKR1USP2 | |
| SCHEMBL4352105 | 0.85 | HRH3 (0.43) | HRH3SIGMAR1USP2ACACBACACA | |
| SCHEMBL4357290 | 0.84 | HRH3 (0.44) | HRH3USP2ACACBACACA | |
| SCHEMBL4353281 | 0.82 | F10 (0.45) | HRH3USP2KDM4EALDH1A1 | |
| SCHEMBL4364137 | 0.81 | HRH3 (0.39) | HRH3USP2ALDH1A1KCNH2 | |
| SCHEMBL4539135 | 0.81 | HRH3 (0.54) | HRH3ACACBACACA | |
| SCHEMBL4565355 | 0.80 | HRH3 (0.40) | HRH3USP2ACACBACACA | |
| SCHEMBL3534123 | 0.77 | HRH3 (0.58) | HRH3CYP2D6KDM4EALDH1A1 | |
| SCHEMBL4364219 | 0.76 | SIGMAR1 (0.43) | HRH3SIGMAR1PROKR1USP2ACACB | |
| SCHEMBL3539835 | 0.75 | HRH3 (0.58) | HRH3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |