Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 14/20 | 0.48 |
| ▸ | GNA15 | P30679 | 1/20 | 0.45 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349242 | 0.89 | FFAR1 (0.47) | MAPTMEN1KMT2AFFAR1GNA15 | |
| SCHEMBL4359443 | 0.87 | MAPT (0.62) | MAPTMEN1KMT2AFFAR1GNA15 | |
| SCHEMBL4358556 | 0.87 | MAPT (0.54) | MAPTMEN1KMT2AFFAR1GNA15 | |
| SCHEMBL4359288 | 0.87 | FFAR1 (0.60) | MAPTMEN1KMT2AFFAR1GNA15 | |
| SCHEMBL4349323 | 0.87 | FFAR1 (0.48) | MAPTMEN1KMT2AFFAR1GNA15 | |
| SCHEMBL4342234 | 0.81 | FAAH (0.42) | FFAR1GNA15PTGER3FFAR4TDP1 | |
| SCHEMBL4354230 | 0.80 | FFAR1 (0.47) | MAPTMEN1KMT2AFFAR1GNA15 | |
| SCHEMBL4354087 | 0.79 | ACLY (0.43) | MAPTMEN1KMT2AFFAR1FAAH | |
| SCHEMBL4354010 | 0.79 | PPARG (0.41) | MAPTFFAR1GNA15PTGER3FFAR4 | |
| SCHEMBL12846780 | 0.78 | FAAH (0.39) | MAPTFFAR1GNA15PTGER3FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-1539683-A2 | PHENOL DERIVATIVES AND THEIR USE AS ROTAMASE INHIBITORS | Jerini AG (DE) | 2005-06-15 | — | — | EP | claimed |
| WO-2004026815-A2 | PHENOL DERIVATIVES AND THEIR USE AS ROTAMASE INHIBITORS | JERINI AG (DE) | 2004-04-01 | — | — | WO | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |